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Yi, Y., Hahm, S.H., and Lee, K.H. Retroviral Gene Therapy:
Safety Issues and Possible Solutions. Current Gene Therapy.
Vol. 25-35, 2005.
Hahm, S.H., Yi Y., Lee, D.K., Noh, M.J., Yun, L.,
and Lee, K.H. Construction of Retroviral Vectors with Enhanced
Efficiency and Safety. J. Virol. Method. Vol. 121: 127-136,
2004.
Hahm, S.H., Chen Y., Vinson, C., and Eiden, L.E. A
calcium-initiated signaling pathway propagated through calcineurin
and CREB activates proenkephalin gene transcription following
depolarization. Mol. Pharm. Vol. 64(6): 1503-1511, 2003.
Hahm, S.H. and Eiden, L.E. A context dependent binding
of AP-1 plays an essential role for cell-specific and inducible
expression of the human vasoactive intestinal peptide gene.
J. Biol. Chem.
Vol. 274(36):25588-255893, 1999.
Lee, H.W., Hahm, S.H., Hsu, C.M., and Eiden, L.E.
Pituitary adenylate cyclase-activating polypeptide regulation
of vasoactive intestinal polypeptide transcription requires
Ca2+ influx and activation of the serine/threonine phosphatase
calcineurin. J. Neurochem. Vol. 73(4):1769-1772, 1999.
Hahm, S.H. and Eiden, L.E. Five discrete cis-active
domains direct cell type-specific transcription of the VIP
gene. J. Biol. Chem., Vol. 273(27):17086-17094, 1998.
Hahm, S.H., Hsu, C.M., and Eiden, L.E. PACAP activates
calcium influx-dependent and -independent pathways to couple
met-enkephalin secretion and biosynthesis in chromaffin cells.
J. Mol. Neurosc., Vol. 11:43-56, 1998.
Hahm, S.H. and Eiden, L.E. Five interactive clusters
of cis-regulatory elements control basal and inducible VIP
gene transcription., Annal. N.Y. Acad. Sci., Vol. 865:10-26,
1998.
Hahm, S.H., Hsu, C.M., and Eiden, L.E. PACAP stimulates
secretion and biosynthesis of enkephalin and VIP by activating
calcium influx and a second calcium influx-independent signaling
pathway. ¡°The Adrenal Chromaffin Cell: Archetype and Exemplar
of Cellular Signaling in Secretory Control.¡± 9th International
Symposium on Chromaffin Cell Biology. Hokkaido University
Press, Sapporo, Japan, pp 89-100, 1998.
Eiden, L.E., Anouar, Y., Hsu, C.M.., MacArthur, L., and Hahm,
S.H. Transcription regulation coupled to calcium and protein
kinase signaling systems through TRE- and CRE-like sequences
in neuropeptide genes. Advances in Pharmacology, Vol. 42:264-268,
1998.
Hahm, S.H., Chen, L., Patel, C., Erickson, J.D., Bonner,
T.I., Weihe, E., Schafer, M.K.-H., and Eiden, L.E. Upstream
sequencing and functional characterization of the human cholinergic
gene locus. J. Mol. Neurosci., Vol. 9(3):223-236, 1997.
Hahm, S.H. and Eiden, L.E. Tissue-specific expression
of the vasoactive intestinal peptide gene requires both an
upstream tissue specifier element and the 5' proximal cAMP-responsive
element. Journal of Neurochemistry, Vol. 67(5):1872-1881,
1996.
Hahm, S.H. and Cooper, R.H. Transforming growth factor-?1
rapidly activates phosphorylase in a calcium-dependent manner
in rat hepatocytes. FEBS Letters, 311 (1):37-40, 1992.
Hahm, S.H. and Saunders, M.J. Cytokinin increases
intracellular Ca2+ in Funaria: detection with indo-1. Cell
Calcium, 12(10):675-81, 1991.
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